Tumor Microenvironment in Head and Neck Squamous Cell Carcinomas.
نویسنده
چکیده
Recent studies about solid tumors demonstrated that tumor microenvironment has an important role in tumor progression, aggressivity, and metastasis process, in addition to genetic aberrations and molecular alterations of cancer cells. Therefore, the crosstalks between cancerous and noncancerous cells and metabolic changes in tumor microenvironment cause significant detrimental effects. The purpose of this review is to present the role and effect of noncancerous cells and their crosstalks with cancer cells, metabolic changes in tumor microenvironment, and to discuss the clinical significance of all these factors with respect to the current literature.
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عنوان ژورنال:
- Seminars in oncology
دوره 41 2 شماره
صفحات -
تاریخ انتشار 2007